Semiconductor Applications

From Diagnostic Imaging to Ophthalmic Procedures and Neuroscience Research to Drug Discovery, Calmar Lasers are enabling the Biomedical World

With the global population both growing and aging, the medical field is increasingly turning to lasers and photonics to enable more effective and lower cost healthcare solutions. Whether it is higher throughput for screening, improved diagnostic capabilities, or more precise surgical procedures, lasers are having a significant impact.

Bio-imaging has benefited greatly from the availability of user-friendly ultrafast laser sources, as multiphoton microscopy has experienced tremendous growth over the past few decades. This technique allows imaging of living tissue with subcellular resolution to depths of a millimeter or more from fluorescence, harmonic generation or nonlinear scattering following the simultaneous excitation of two or three near-infrared photons.  There is significant effort underway to translate the technology to the clinical setting with different platforms being explored as an optical biopsy solution.  And the Carmel X-series is the perfect ultrafast fiber laser to enable that transition.  With its air-cooled, rack-mounted controller and ultra compact laser head facilitating straight forward integration into microscope platforms with minimal delivery optics, Carmel X has become the laser of choice for bio-imaging applications,

Ultrafast lasers have also found wide spread use in laser corrective eye surgery, the Cazadero and Carmel have proven to be excellent sources for corneal flap-cutting procedures in LASIK, femtosecond cataract surgery or refractive index shaping of intraocular lenses.  And for medical OEMs building their own laser system, the Mendocino provides the ultimate rock-solid femtosecond laser seed source.

New bio-instrumentation platforms are also benefiting from the incorporation of compact ultrafast lasers and pushing the frontiers of cancer research.  The Mendocino and Carmel platforms are enabling high throughput second harmonic generation measurements to determine subtle changes in protein conformation for allosteric drug discovery, 3D printing of living cells and tissue scaffolds, two-photon cleaving for spatial profiling of pathology specimens for resolving tissue heterogeneities and much more.

Whether it be a robust, low power, seed laser source such as the Mendocino or a higher power laser, such as the Carmel or Cazadero, Calmar offers an ultrafast fiber laser solution for your biomedical applications.

Multiphoton Exoscope Broadens Noninvasive Imaging of Skin | Features | Sep/Oct 2023 | BioPhotonics

Multiphoton Microscopy Technique Advances into Clinical Settings | Research & Technology | Dec 2021 |

Compact Ultrafast Fiber Lasers Enable Applications in New Spaces

Karsten König, Ana Batista, Michael Zieger, Martin Kaatz, Holger Hänssle, Christine Fink, Hans Georg Breunig, "Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser," Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110E (24 February 2020); doi: 10.1117/12.2542322

Karsten König, Ana Batista, Aisada König, Hans Georg Breunig,"Multimodal multiphoton tomograph using a compact femtosecond fiber laser,"Proc. SPIE 10882, Multiphoton Microscopy in the Biomedical Sciences XIX, 108821A (22 February 2019); doi: 10.1117/12.2509551

McLennan, H.J., Blanch, A.J., Wallace, S.J. et al. Nano-liter perfusion microfluidic device made entirely by two-photon polymerization for dynamic cell culture with easy cell recovery. Sci Rep 13, 562 (2023).

Delaey, J.Parmentier, L.Pyl, L.Brancart, J.Adriaensens, P.Dobos, A.Dubruel, P.Van Vlierberghe, S.Solid-State Crosslinkable, Shape-Memory Polyesters Serving Tissue Engineering. Macromol. Rapid Commun. 202344, 2200955.